abstract：OBJECTIVES:To determine the effects of an intravenous bolus dose of a vasopressin analogue, terlipressin (1 mg), on systemic haemodynamic parameters and gastric mucosal perfusion (GMP) in patients with catecholamine-treated septic shock using a gastric tonometry and laser-Doppler flowmetry technique. DESIGN:Prospectiv...

journal_title：Intensive care medicine

authors： Morelli A,Rocco M,Conti G,Orecchioni A,De Gaetano A,Cortese G,Coluzzi F,Vernaglione E,Pelaia P,Pietropaoli P

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:While using a transcutaneous system for assessment of liver function by indocyanine green plasma disappearance rate (ICG-PDR) in critically ill patients, we compared the agreement between ICG-PDR obtained by the recommended standard ICG dosage (0.5 mg/kg) and a reduced dosage (0.25 mg/kg). DESIGN:Clinical st...

journal_title：Intensive care medicine

authors： Sakka SG,Koeck H,Meier-Hellmann A

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:Interhospital transfers of critically ill pediatric patients in The Netherlands are accompanied by referring specialists or by specialist retrieval teams. We compared the interventions before and directly after transports and the complications and the equipment available during transports in the two groups. ...

journal_title：Intensive care medicine

authors： Vos GD,Nissen AC,H M Nieman F,Meurs MMB,van Waardenburg DA,Ramsay G,Donckerwolcke RAMG

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To derive recommendations for the dosing of commonly used medications in the morbidly obese patient in the ICU. DATA SOURCES:Articles were obtained through computerized searches involving MEDLINE. The bibliographies of retrieved publications and textbooks were reviewed for additional references. STUDY SELEC...

journal_title：Intensive care medicine

authors： Erstad BL

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Measurement of functional residual capacity (FRC) during mechanical ventilation is important to standardise respiratory system compliance and adjust the ventilator settings to optimise lung recruitment. In the present study we compared three methods to measure FRC. DESIGN:The bias flow nitrogen washout techn...

journal_title：Intensive care medicine

authors： Schibler A,Hammer J,Isler R,Buess C,Newth CJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:(a). To describe the glucose content of normal human airways secretions; (b). to observe the effects of hyperglycemia and airways inflammation on airways glucose. DESIGN:Observational studies. SETTINGS:(a). St George's Hospital Medical School; (b). diabetes mellitus outpatient clinics; (c). adult general i...

journal_title：Intensive care medicine

authors： Philips BJ,Meguer JX,Redman J,Baker EH

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Candidemia is increasingly encountered in critically ill patients with a high fatality rate. The available data in the critically ill suggest that patients with prior surgery are at a higher risk than others. However, little is known about candidemia in medical settings. The main goal of this study was to com...

journal_title：Intensive care medicine

authors： Charles PE,Doise JM,Quenot JP,Aube H,Dalle F,Chavanet P,Milesi N,Aho LS,Portier H,Blettery B

更新日期：2003-12-01 00:00:00

abstract：:Helicobacter pylori is estimated to infect over 50% of the world's population, the majority of whom are asymptomatic. Although most research to date has focused on local gastroduodenal disease manifestations, the potential impact of H. pylori infection and the associated chronic active inflammation on systemic disease...

journal_title：Intensive care medicine

authors： Robertson MS,Clancy RL,Cade JF

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:We compared two imipenem regimens for prevention of septic complications in patients with severe acute necrotizing pancreatitis (ANP). DESIGN AND SETTING:Prospective, randomized open clinical trial involving intensive care units of 14 Spanish Hospitals. PARTICIPANTS:92 patients with ANP. INTERVENTIONS:Imip...

journal_title：Intensive care medicine

authors： Maraví-Poma E,Gener J,Alvarez-Lerma F,Olaechea P,Blanco A,Domínguez-Muñoz JE,Spanish Group for the Study of Septic Complications in Severe Acute Pancreatitis.

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:To assess the attitudes of physicians in Milan, Italy, intensive care units (ICUs) regarding end-of-life decisions. DESIGN:Anonymous self-administered questionnaire. SETTING:All 20 ICUs in Milan. PARTICIPANTS:Physicians employed in the ICUs. MEASUREMENTS AND RESULTS:The response rate was 87% (225 of 259)....

journal_title：Intensive care medicine

authors： Giannini A,Pessina A,Tacchi EM

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:To investigate the sources of hemorrhage and use of endoscopic hemostasis in patients with clinically significant upper gastrointestinal (UGI) hemorrhage after admission to the intensive care unit (ICU). DESIGN AND SETTING:Prospective study, 123 beds of ICU in a 1,629-bed medical center. MEASUREMENTS AND RE...

journal_title：Intensive care medicine

authors： Lee YC,Wang HP,Wu MS,Yang CS,Chang YT,Lin JT

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Sepsis-evoked myocardial dysfunction is possibly due to decreased myofilament calcium sensitivity, and a calcium sensitizer may thus specifically improve contractility in sepsis by enhancing myofilament calcium sensitivity. We examined whether the calcium sensitizer levosimendan mitigates myocardial dysfuncti...

journal_title：Intensive care medicine

authors： Behrends M,Peters J

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To evaluate whether helium-oxygen mixture reduces inspiratory work of breathing (WOB) in sedated, paralyzed, and mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). DESIGN AND SETTING:Open, prospective, randomized, crossover study in the medical intensive...

journal_title：Intensive care medicine

authors： Gainnier M,Arnal JM,Gerbeaux P,Donati S,Papazian L,Sainty JM

更新日期：2003-10-01 00:00:00

abstract：:Male gender predisposes to severe sepsis and septic shock. This effect has been ascribed to higher levels of testosterone. The ESPNIC ARDS database was searched, to determine if there was evidence of a similar male preponderance in severe sepsis in prepubertal patients in spite of low levels of male sex hormones at th...

journal_title：Intensive care medicine

authors： Bindl L,Buderus S,Dahlem P,Demirakca S,Goldner M,Huth R,Kohl M,Krause M,Kühl P,Lasch P,Lewandowski K,Merz U,Moeller J,Mohamad Y,Peters M,Porz W,Vierzig A,Rüchard J,Scharf J,Varnholt V,ESPNIC ARDS Database Group.

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND SETTING:Prospective animal study in a university laboratory for experimental. SUBJECTS:140 male Wis...

journal_title：Intensive care medicine

authors： Ritter C,Andrades M,Frota Júnior ML,Bonatto F,Pinho RA,Polydoro M,Klamt F,Pinheiro CT,Menna-Barreto SS,Moreira JC,Dal-Pizzol F

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence and the circumstances of a moderate increase in serum creatinine early after elective abdominal aortic surgery. DESIGN:Prospective clinical observational study. SETTING:Surgical intensive care unit in a university hospital. PATIENTS:Two hundred and fifteen consecutive adult patien...

journal_title：Intensive care medicine

authors： Ryckwaert F,Alric P,Picot MC,Djoufelkit K,Colson P

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:This study compared the recently introduced Microcuff endotracheal tube HVLP ICU featuring an ultrathin (7-microm) polyurethane cuff membrane with endotracheal tubes from different manufacturers regarding fluid leakage past the tube cuff. DESIGN:In vitro setup. MEASUREMENTS AND RESULTS:The following endotra...

journal_title：Intensive care medicine

authors： Dullenkopf A,Gerber A,Weiss M

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To define the changes in middle cerebral artery flow velocity (Vmca) and the electroencephalogram (EEG) during rapid reduction in arterial carbon dioxide (PCO2) from acute hypercapnia. DESIGN. Human volunteer study. SETTING:University-affiliated hospital experimental laboratory. PARTICIPANTS:Nine healthy vo...

journal_title：Intensive care medicine

authors： Halpern P,Neufeld MY,Sade K,Silbiger A,Szold O,Bornstein NM,Sorkine P

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To provide evidence for the upregulation of endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) in the assumed imbalance in the pathophysiology of rapid progressive pulmonary hypertension of the newborn (RPPHN), which is characterized by abnormal hypertrophy of the pulmonary art...

journal_title：Intensive care medicine

authors： Hoehn T,Preston AA,McPhaden AR,Stiller B,Vogel M,Bührer C,Wadsworth RM

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To document the costs and outcomes of the various forms of the septic syndromes [systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock), particularly those associated with infection acquired in an intensive care unit (ICU). DESIGN:Prospective data collection for all septic patie...

journal_title：Intensive care medicine

authors： Brun-Buisson C,Roudot-Thoraval F,Girou E,Grenier-Sennelier C,Durand-Zaleski I

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To determine whether health-related quality of life (HRQL) in survivors of acute renal failure (ARF) occurring in intensive care is predictable from data available at the time of acute illness. DESIGN AND SETTING:Prospective pilot study in academic intensive care units. PATIENTS AND METHODS:Patients requiri...

journal_title：Intensive care medicine

authors： Maynard SE,Whittle J,Chelluri L,Arnold R

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:A case-control comparison of Doppler guidance on the success rate of central venous cannulation in patients with normal or reduced intracranial compliance. DESIGN:A single operator performed central venous access procedures with continuous wave Doppler guidance. It was used on patients on a ventilator. The p...

journal_title：Intensive care medicine

authors： Schummer W,Schummer C,Niesen WD,Gerstenberg H

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To explore the consequences of helium/oxygen (He/O(2)) inhalation on respiratory mechanics, gas exchange, and ventilation-perfusion (VA/Q) relationships in an animal model of severe induced bronchospasm during mechanical ventilation. DESIGN:Prospective, interventional study. SETTING:Experimental animal labo...

journal_title：Intensive care medicine

authors： Watremez C,Liistro G,deKock M,Roeseler J,Clerbaux T,Detry B,Reynaert M,Gianello P,Jolliet P

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To measure muscle blood flow (Qtis) and oxygen consumption (VO(2)tis) in septic and non-septic critically ill patients by near-infrared spectroscopy (NIRS). SETTING:Surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS:Four patients with septic shock, eight post-surgical criticall...

journal_title：Intensive care medicine

authors： Girardis M,Rinaldi L,Busani S,Flore I,Mauro S,Pasetto A

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To describe the clinical course of quinine-induced disseminated intravascular coagulation (DIC) and review all previous cases reported in the medical literature. DESIGN:Case report/literature review. SETTING:University teaching hospital medical ICU. PATIENTS:One patient in whom thrombocytopenia, coagulopat...

journal_title：Intensive care medicine

authors： Knower MT,Bowton DL,Owen J,Dunagan DP

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Antipyrine metabolism is a "gold standard" measure of mixed cytochrome P450 (CYP) mediated drug metabolism in humans. Cytokines (e.g., interleukin-6) and nitric oxide reduce CYP 450 activity in vitro and in vivo. Because interleukin-6 and nitric oxide production increases in children with sepsis-induced multi...

journal_title：Intensive care medicine

authors： Carcillo JA,Doughty L,Kofos D,Frye RF,Kaplan SS,Sasser H,Burckart GJ

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:The objective was to identify factors associated with thrombocytopenia and to assess to what extent thrombocytopenia increases bleeding complications in liver transplant patients. DESIGN:Retrospective study. SETTING:Surgical intensive care unit in a university hospital. PATIENTS:One hundred and sixty-one p...

journal_title：Intensive care medicine

authors： Ben Hamida C,Lauzet JY,Rézaiguia-Delclaux S,Duvoux C,Cherqui D,Duvaldestin P,Stéphan F

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Evaluation of an open circuit multiple breath nitrogen washout (MBNW) technique for measurement of functional residual capacity (FRC) during partial ventilatory support using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen. DESIGN:Measurements in a lung model with known reference...

journal_title：Intensive care medicine

authors： Zinserling J,Wrigge H,Varelmann D,Hering R,Putensen C

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:To compare the efficiency of non-invasive positive pressure ventilation (NPPV) in decompensated patients with either chronic obstructive pulmonary disease (COPD) or chronic restrictive pulmonary disease. DESIGN:Retrospective study. SETTING:A 17-bed intensive care unit in a university teaching hospital. SET...

journal_title：Intensive care medicine

authors： Robino C,Faisy C,Diehl JL,Rezgui N,Labrousse J,Guerot E

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To assess procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations and clearance in nonseptic end-stage renal failure patients undergoing their first three hemodialysis sessions. DESIGN AND SETTING:Prospective observational consecutive clinical study at a university hospital. PATIENTS:The stud...

journal_title：Intensive care medicine

authors： Dahaba AA,Rehak PH,List WF

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To study whether transient hyperglycemia adversely affects cerebral energy metabolism in patients with severe traumatic brain lesions. DESIGN AND SETTING:Prospective, nonrandomized study in the neurosurgical intensive care unit of a university hospital. PATIENTS:108 patients treated for severe traumatic bra...

journal_title：Intensive care medicine

authors： Diaz-Parejo P,Ståhl N,Xu W,Reinstrup P,Ungerstedt U,Nordström CH

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation between microalbuminuria and extravascular lung water in patients in septic shock who require mechanical ventilation for severe respiratory failure. DESIGN AND SETTING:Prospective, observational, clinical study in the 20-bed intensive care unit of a university hospital. PATIEN...

journal_title：Intensive care medicine

authors： Molnár Z,Szakmány T,Heigl P

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:We assessed the methodological trial quality of individual randomized controlled studies on chlorhexidine silver sulfadiazine impregnated catheters and the effect on catheter-related infection (CRI). DESIGN:Only the studies identified in the Medline database from 1966 to December 2001 were considered, abstra...

journal_title：Intensive care medicine

authors： Geffers C,Zuschneid I,Eckmanns T,Rüden H,Gastmeier P

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:Real-time measurement of stroke volume variation by arterial pulse contour analysis (SVV) is useful in predicting volume responsiveness and monitoring volume therapy in mechanically ventilated patients. This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of f...

journal_title：Intensive care medicine

authors： Reuter DA,Bayerlein J,Goepfert MS,Weis FC,Kilger E,Lamm P,Goetz AE

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between the base deficit value in the immediate postoperative period of coronary surgery for cardiopulmonary bypass and the length of stay in the ICU. DESIGN AND SETTING:Prospective descriptive study in the department of anesthesia and cardiovascular surgery of a university hospita...

journal_title：Intensive care medicine

authors： Hugot P,Sicsic JC,Schaffuser A,Sellin M,Corbineau H,Chaperon J,Ecoffey C

更新日期：2003-02-01 00:00:00

abstract：:The abundance of literature related to nutritional support reflects its recently recognised role in preventing metabolic complications and gut dysfunction during critical illness. However, some published studies lack relevance to critically ill patients, as a result of the selection of subjects and outcome variables, ...

journal_title：Intensive care medicine

authors： Preiser JC,Chioléro R,Wernerman J,ESICM(European Society of Intensive Care Medicine) Working Group on Nutrition and Metabolism.

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To determine whether a goal-directed terlipressin infusion increases mean arterial pressure without causing a pulmonary vasopressive effect and whether this response impacts on key parameters of oxygen transport in healthy and endotoxemic sheep. DESIGN AND SETTING:Prospective controlled trial in a university...

journal_title：Intensive care medicine

authors： Westphal M,Stubbe H,Sielenkämper AW,Borgulya R,Van Aken H,Ball C,Bone HG

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the effect of lung volume changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated patients, since we hypothesized that ELIC may be a suitable parameter to monitor lung volume change at the bedside. DESIGN:Clinical trial on patients requiring m...

journal_title：Intensive care medicine

authors： Hinz J,Hahn G,Neumann P,Sydow M,Mohrenweiser P,Hellige G,Burchardi H

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:We examined in rabbits the effects of more than 48 h of mechanical ventilation on the contractile properties and fiber type adaptations of the respiratory muscles. DESIGN AND SETTING:Experimental prospective study in a university laboratory. ANIMALS AND INTERVENTIONS:Nineteen rabbits were randomly allocated...

journal_title：Intensive care medicine

authors： Capdevila X,Lopez S,Bernard N,Rabischong E,Ramonatxo M,Martinazzo G,Prefaut C

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the physiological effects of decannulation on breathing patterns and respiratory mechanics by comparing mouth breathing (MB) to tracheal breathing (TB) in tracheostomized patients. DESIGN AND SETTING:Prospective cross-over study in a critical and neuromuscular care unit. PATIENTS AND METHODS:Nin...

journal_title：Intensive care medicine

authors： Chadda K,Louis B,Benaïssa L,Annane D,Gajdos P,Raphaël JC,Lofaso F

更新日期：2002-12-01 00:00:00